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KMID : 0895420050150020124
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Journal of Korean Society of Occupational and Enviromental Hygiene
2005 Volume.15 No. 2 p.124 ~ p.134
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Biological Monitoring of Paint Handling Workers exposed to PAHs using Urinary 1-Hydroxypyrene
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Lee Jong-Seong
Kim Eun-A
Lee Yong-Hag
Moon Deog-Hwan
Kim Kwang-Jong
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Abstract
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To investigate the exposure effect of polyriuclear aromatic hydrocarbons (PAHs), we measured airborne total PAHs as an external dose, urinary 1-hydroxypyrene (1 -0HP) as an internal dose of PAHs exposure, and analyzed the relationship between urinary 1-OHP concentration and PAHs exposure. The study population contained 44 workers in steel-pipe coating and paint manufacture industries. The airborne PAHs was obtained during survey day, and urine were sampled at the end of shift. Personal information on age, body weight, height, eniployment duration, smoking habit, and alcohol consumption was obtained by a structured questionnaire. Airborne PAHs were analyzed by the gas chromatograph with mass selective detector. Urinary 1 -0HP levels were analyzed by the high performance liquid chromatograph with ultraviolet wavelength detector. For statistical estimation, t-test. X-test, analysis of variance. correlation analysis, arid regression analysis were executed by SPSS/PC (Windows version 10). The mean of environmental total PAHs was 87.8’7.81 p d m . The mean concentration (526.5’2.85 p d m ) of workers in steel-pipe coating industries using coal tar ellamel was the higher than that (17.5k3.36 pglnf) of workers in paint manufacture industries using coal tar paint. The mean of urinary 1 -0HP concentration (51.63 ’ 3.1 44 p mol/mol creatinine) of workers in steel-pipe coating indl~stries was the higher than that (2.33*4.709 p mol/rnol creatinine) of workers in paint manufacture iridustries. The mean of i~ririary 1-OHP concentration of smokers was the higher than that of non-smokers. There was significant correlatiori between the urinary concentration of 1 -0HP and the environmental concentration of PAHs (r=O.S48, p<0.001), pyrene(r=0.859, p<0.001), and urinary cotinine (r=0.324, p<0.05). The regression equation between the urinary concentration of I -0HP in pg/g creatinine(C1 (11’) and airborne concentration of PAHs (or pyrene) in pg/m’ (CI’III. or Cpyrene) is: Log (CI-~II=I ~-0). 650 + 0.889 x Log ( C ~ \ \ IwIh~e,r e R2=0.694a rid n=38 for p<0.001. Log (Cl-rrii) = 1.087 + 0.707 x Log (Cpyrene), where R2=0.713 arid n=38 for p<0.001. From the resdts of stepwise multiple regression analysis about 1 -OHP, significant independents were total PAHs and urinary cotinine (adjusted K’=0.743, p<0.001). In this study, there were significant correlation between the urinary concentration of 1-OHP and the airborne concentration of PAHs. The urinary 1 -0HP was effective index as a biomarker of airborne PAHs in workplace. But it was influenced by non-occupational PAHs source, smoking.
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KEYWORD
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Cotiriine, Coal-tar, 1-Hydroxypyrene, Polyriuclear aromatic hydrocarbons
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